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KMID : 0861020040190010023
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Korea Journal of Herbology
2004 Volume.19 No. 1 p.23 ~ p.34
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Effect of Polygoni Multiflori Radix and Cynanchi Wilfordii Radix On Prevention of Osteoporosis In Ovariectomized Rats
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김민정/Kim, Min-Jeong
서부일/신순식/박지하/Seo, Bu-Il/Shin, Soon-Shik/Park, Ji-Ha
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Abstract
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Objectives : The present study has been undertaken to investigate the effects of Polygoni Multiflori Radix and Cynanchi Wilfordii Radix on prevention of osteoporosis in ovariectomized rats.
Methods : In this experiment, the rats were ovariectomized. Rats were administered by 2 kinds of medicine, Polygoni Multiflori Radix and Cynanchi Wilfordii Radix. The levels of bone mineral density, osteocalcin, ALP, phosphorus, calcium in serum, calcium, phosphorus in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured.
Results : The levels of spinal bone mineral density was significantly increased in comparison with OVX group at 6 weeks in Polygoni Multiflori Radix group.
The levels of serum ALP showed significant decrease in comparison with OVX group at 3 weeks in Polygoni Multiflori Radix group, and showed significant decrease in comparison with OVX group at 3, 6 weeks in Cynanchi Wilfordii Radix group. The levels of serum phosphorus showed significant decrease in Comparison with OVX group at 3, 6 weeks in Polygoni Multiflori Radix and Cynanchi Wilfordii Radix group.
The levels of femoral and fibula-tibial calcium showed significant increase in comparison with OVX group in Polygoni Multiflori Radix and Cynanchi Wilfordii Radix group. The levels of femoral phosphorus showed significant increase in comparison with OVX group at 3 weeks in Polygoni Multiflori Radix and Cynanchi Wilfordii Radix group.
Conclusions : Reviewing these experimetal results, it appears that Polygoni Multiflori Radix and Cynanchi Wilfordii Radix have efficacy on prevention of osteoporosis. And further study should be conducted to illustrate in depth the curing osteoporosis.
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